Ronald Witteles, MD, Stanford University, Stanford, CA, comments on the current therapeutic landscape for light chain (AL) amyloidosis, highlighting the significant progress made in lowering light chain levels and directly targeting clonal plasma cells, notably with the approval of daratumumab. Dr Witteles also emphasizes his enthusiasm for the potential of bispecific antibodies and CAR-T therapy for AL amyloidosis following positive early data. This interview took place during the 2026 European Society of Cardiology (ESC) Congress in Munich, Germany.
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