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EBMT 2026 | A systematic review & meta-analysis evaluating belumosudil for treating refractory chronic GvHD

Fernando Gibran-Nunes, MD, Hospital Sirio-Libanês, São Paulo, Brazil, briefly outlines findings from the first systematic review and meta-analysis evaluating the selective oral ROCK2 inhibitor, belumosudil, in patients with refractory chronic graft-versus-host disease (GvHD), highlighting favorable tolerability and efficacy. This interview took place at the 52nd Annual Meeting of the EBMT in Madrid, Spain.

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Transcript

Belomusodil is a new drug. We don’t have a lot of options for this population of chronic GVHD. So it was the first systematic review and meta-analysis of this drug. And we gathered more than 400 patients. And the drug showed an interesting overall response, the overall response rate was more than 50% and the tolerability was also good with less than 5% of patients discontinuing due to adverse events and the duration of response was also more than 50 weeks...

Belomusodil is a new drug. We don’t have a lot of options for this population of chronic GVHD. So it was the first systematic review and meta-analysis of this drug. And we gathered more than 400 patients. And the drug showed an interesting overall response, the overall response rate was more than 50% and the tolerability was also good with less than 5% of patients discontinuing due to adverse events and the duration of response was also more than 50 weeks. So it was a very interesting drug to use in this very pre-treated population.

 

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