Pavan Reddy, MD, University of Michigan Medical Center, Ann Arbor, MI, describes highlights from the Transplantation & Cellular Therapy (TCT) 2021 Meeting, and discusses how the change in platform impacted audience participation. Dr Reddy also explores the latest data presented at the meeting, including advances in CAR T-cell therapy and updates in graft-versus-host disease prophylaxis, as well as the importance of integrating the ongoing COVID-19 pandemic as well as the importance of diversity into the meeting program. This interview took place during the Transplantation & Cellular Therapy (TCT) 2021 Meetings.