Dan Landau, MD, PhD, of Weill Cornell Medical College and the NYGC, New York, NY, discusses why he strongly believes in centers working collaboratively. All of the work these centers do, is almost invariably cutting across disciplinary boundaries. Dr Landau refers to his own experience of working collaboratively and crossing these disciplinary boundaries, mentioning that it allows for innovation by borrowing concepts from one field to another. He provides an example of how his previous work with statistical genetics, allowed him to come up with a new perspective to look at epigenomics, by virtue of coming from a different field. Dr Landau mentions his plans to continue working collaboratively, stating that we are in an environment where there is immense data, whereby researchers need to be collaboratively smart in leveraging and thinking about. He mentions that the Genome Center has a mission to serve as a hub; people from New York and the rest of the world can bring their data to come up with new ways of thinking, and therefore new therapies. Recorded at the 2016 International Workshop of the German CLL Study Group (GCLLSG) in Cologne, Germany.