Dan Landau, MD, PhD, of Weill Cornell Medical College and the NYGC, New York, NY, talks about applying data from chronic lymphocytic leukemia (CLL) to other cancer types. CLL is a relatively simple case of a complex problem, genetically it is a relatively more stable disease compared to other cancers. The ability to leverage large data sets, to come up with these evolutionary maps that map up sequences of events, are now being applied across cancers to come up with a framework to study this more broadly. The paradigm of clonal kinetics to guide therapy that Dr Landau talked about, are now being explored through multiple projects, including liquid biopsy technology. Recorded at the 2016 International Workshop of the German CLL Study Group (GCLLSG) in Cologne, Germany.