Barbara Eichhorst, MD of the University of Cologne, Cologne, Germany, how to take care of the mental well-being of chronic lymphocytic leukemia (CLL) patients. For patients in the wach-and-wait period, particularly in the first year, it helps if they are seen on a regular basis; it is important for them to build and maintain self-confidence. It is important to make sure they get their vaccinations and that after the first 1-2 years, if they have s a slowly progressing CLL, that they are mentally stable. For those patients who receive a long, continuous therapy, it is essential to monitor them closely due to potential toxicities, which can occur later during the administration. It is also important to make sure the patient is still compliant, i.e. taking their therapy Recorded at the 2016 International Workshop of the German CLL Study Group (GCLLSG) in Cologne, Germany.