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ERIC 2024 | BTK degraders for CLL: agents that are currently in development
William Wierda, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the potential of BTK degraders for patients with chronic lymphocytic leukemia (CLL) who have failed previous BTK inhibitor therapies. He highlights the development of NX-5948, a BTK-only degrader, and expresses optimism about the broader implications of protein degradation technology in targeting other cellular proteins for therapeutic purposes. This interview took place at the 2024 European Research Initiative on CLL (ERIC) Meeting in Barcelona, Spain.
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Disclosures
Contracted Research: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Bristol-Myers Squibb Company, Cyclacel Pharmaceuticals Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, GlaxoSmithKline, Janssen Biotech Inc, Juno Therapeutics, a Celgene Company, Kite, A Gilead Company, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Miragen Therapeutics Inc, Novartis, Oncternal Therapeutics, Pharmacyclics LLC, an AbbVie Company, Sunesis Pharmaceuticals Inc, Xencor; Nonrelevant Financial Relationship: National Comprehensive Cancer Network (Chair, CLL).
