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SOHO 2024 | The diagnosis and management of MDS/MPN with neutrophilia (atypical CML)

Massimo Breccia, MD, Sapienza University, Rome, Italy, discusses the diagnosis and treatment of myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia, a malignancy previously known as atypical chronic myeloid leukemia (CML). The diagnosis of this disease is assisted by next-generation sequencing (NGS), and the malignancy must be accurately distinguished from chronic myelomonocytic leukemia (CMML) and chronic neutrophilic leukemia (CNL). The prognosis of patients with this rare disease remains poor and novel therapeutic strategies must be developed. This interview took place at the Twelfth Annual Meeting of the Society of Hematologic Oncology (SOHO 2024) congress in Houston, TX.

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