ASH 2024 | The potential for epigenetic interventions to improve the functioning of CAR T-cells
Alaa Ali, MD, Georgetown University School of Medicine, Washington, DC, comments on the importance of epigenetics in the functioning of CAR T-cells, highlighting the potential for epigenetic interventions to improve CAR T-cell efficacy and reduce toxicities. Dr Ali emphasizes the need for investment in the field of epigenetics to potentially improve CAR T-cell therapy. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Transcript (AI-generated)
Epigenetics is the field that studies the changes in gene expression without changing the sequence of the underlying DNA, but rather modifying biological processes such as DNA methylation or histone modification or chromatin remodeling. Those processes are very important for the function of T-cells in general, but also the function of CAR T-cells. And they can be important in maintaining the persistence and activity of those cells...
Epigenetics is the field that studies the changes in gene expression without changing the sequence of the underlying DNA, but rather modifying biological processes such as DNA methylation or histone modification or chromatin remodeling. Those processes are very important for the function of T-cells in general, but also the function of CAR T-cells. And they can be important in maintaining the persistence and activity of those cells. So what we propose in our opinion paper is to invest in that field to improve the efficacy of CAR T-cells and take advantage of that field to either come up with pharmacological interventions or even gene editing methodologies to actually take leverage of the field of epigenetics to improve the efficacy of those CAR T-cells. So we called for all the stakeholders, including policymakers and research funding agencies, to invest in the field to try to improve the function and reduce the toxicities of CAR T-cell therapies.
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