iwCLL 2023 | Explainable machine learning to identify CLL-driven changes on the gut microbiome

Carsten Niemann, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, explains the effect of the gut microbiome (GM) on the immune system and development of malignancies, and describes the findings of a study comparing the GM of patients with chronic lymphocytic leukemia (CLL) to those with other hematological malignancies, those undergoing surgery, and healthy controls. The GM in disease states varies to that of healthy individuals and using GM data in conjunction with explainable machine learning may allow patterns of bacterial strains or lack of bacterial diversity in disease states to be identified. Using this information, interventions could be put into place to change the GM of those with CLL, to improve immune function or delay disease progression. This interview took place at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2023 meeting, held in Boston, MA.

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