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ASH 2025 | Second-line therapy outcomes in CML after frontline second-generation TKI failure

Fadi Haddad, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses outcomes of patients with chronic myeloid leukemia (CML) who required second-line therapy after frontline second-generation tyrosine kinase inhibitors (TKIs). Dr Haddad highlights that most patients achieved meaningful responses after switching treatment, with particularly favorable outcomes seen with newer-generation TKIs. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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