So we also presented at this year’s ASH annual meeting, a poster from the REVEAL study. So the REVEAL is the largest prospective observational study of patients with polycythemia vera ever conducted. Patients were enrolled. 2,500 patients were enrolled in this study, in fact, and were monitored for a minimum of 36 months. The average duration of observation though was over six years. And from this database we can pull out all kinds of wonderful studies looking at lots of different aspects of polycythemia vera...
So we also presented at this year’s ASH annual meeting, a poster from the REVEAL study. So the REVEAL is the largest prospective observational study of patients with polycythemia vera ever conducted. Patients were enrolled. 2,500 patients were enrolled in this study, in fact, and were monitored for a minimum of 36 months. The average duration of observation though was over six years. And from this database we can pull out all kinds of wonderful studies looking at lots of different aspects of polycythemia vera. So last year we reported that increasing white counts and increasing platelet counts were associated with thrombosis. Most importantly, increasing white counts, especially when the hematocrit is under good control.
This year we took a look at the same REVEAL database and started looking at, well, if you can use another medication to try to control these counts, do patients still do well? And particularly with an interest in ruxolitinib and trying to develop real-world, if you will, evidence for the use of ruxolitinib in this setting. And the bottom line from this abstract was that the use of ruxolitinib in this prospective study, which is more of a real-world study, again, those results with ruxolitinib do definitely reflect what was seen in the clinical trials. So the real-world application of the clinical trials seems to impart the same effect that the clinical trials did, which is incredibly positive.