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EHA 2025 | Opportunities to combine mitapivat with other therapies in clinical trials
Maria Domenica Cappellini, MD, University of Milan, Milan, Italy, comments on the potential for combining mitapivat with other therapies, such as gene therapy or luspatercept, in clinical trials. Prof. Cappellini suggests that combining mitapivat and luspatercept may increase efficacy, but notes that designing a clinical trial with these two agents will be challenging until mitapivat is registered. This interview took place at the 30th Congress of the European Hematology Association (EHA) in Milan, Italy.
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Transcript
This is a very good question and scientifically speaking the answer is yes, because considering the mechanism of action of mitapivat, which is improving the metabolism of the red cells, so it’s increasing the energy production through the ATP. And the mechanism of action, for example, of luspatercept, I personally believe that the combination of the two will increase the efficacy, the results...
This is a very good question and scientifically speaking the answer is yes, because considering the mechanism of action of mitapivat, which is improving the metabolism of the red cells, so it’s increasing the energy production through the ATP. And the mechanism of action, for example, of luspatercept, I personally believe that the combination of the two will increase the efficacy, the results. But as you know, whenever you have two different compounds from two different companies, it will be difficult to design a proper clinical trial. It could be done as soon as – the drug luspatercept, of course, is already registered – as soon as mitapivat will be registered, I mean, we may design an independent study and do that. With gene therapy we still need to have some more data but it can be also an option.
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