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EHA 2025 | Complications of treatment with 7+3 chemotherapy versus CPX-351 in AML and secondary AML

Livio Pagano, MD, Catholic University of Sacred Heart, Rome, Italy, discusses complications of treatment with 7+3 chemotherapy versus CPX-351 in acute myeloid leukemia (AML) and secondary AML. Prof. Pagano highlights an animal study that showed that CPX-351 treatment preserves gastrointestinal function and microbiota, unlike 7+3, which causes significant damage to the epithelium and damages the microbiota. This interview took place at the 30th Congress of the European Hematology Association (EHA) in Milan, Italy.

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Transcript

We have studied in animal model the difference between CPX and 3 plus 7, two conventional treatments that usually are for patients with acute myloid leukemia and secondary acute myeloid leukemia. And in the study in animal model followed the observation that the patients that received the CPX have no cases of neutropenic enterocolitis. So we have no evidence of an increase over this kind of complication...

We have studied in animal model the difference between CPX and 3 plus 7, two conventional treatments that usually are for patients with acute myloid leukemia and secondary acute myeloid leukemia. And in the study in animal model followed the observation that the patients that received the CPX have no cases of neutropenic enterocolitis. So we have no evidence of an increase over this kind of complication. Starting from this point in animal model we analyzed in the mouse that received both the drugs the situation of the gastroenteric tract and the of the microbiota. And we observed a really difference between the two groups. While patients that receive the conventional chemotherapy have an important damage over the epithelium and the microbiota was completely destroyed. In those patients that receive the CPX there is not any damage so eubiosis and the patients that can survive without no relevant problem for the gastrointestinal tract.

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