Marion Subklewe, MD, Ludwig-Maximilians-University of Munich, Munich, Germany, comments on the development of novel bispecific antibodies (bsAbs) for large B-cell lymphoma (LBCL). BsAbs have demonstrated encouraging efficacy and toxicity profiles in multiple clinical trials, culminating in the pending approval of epcoritamab and glofitamab. Compared to CAR-T therapies, bsAbs have favorable safety profiles and have consequently the potential to be in first-line combination therapies. This interview took place at the 7th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) in Berlin, Germany.
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