The Lymphoma Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), BMS (Gold), Johnson & Johnson (Gold), Takeda (Silver) and Galapagos (Bronze). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
SITC 2021 | Efficacy of bispecific CD19/CD22 CAR T-cells in B-cell malignancies
Crystal Mackall, MD, Stanford University, Stanford, CA, explains the rationale and the results from a Phase I trial investigating the safety and efficacy of a bispecific chimeric antigen receptor (CAR) T-cell targeting CD19 and CD22 in combination with chemotherapy in adult patients with recurrent or refractory B-cell malignancies (NCT03233854). Previous studies have revealed that up to two thirds of patients treated with CAR T-cell therapy relapse because of antigen modulation, either by complete loss or by downregulation of the CD19 target antigen. Monospecific CD22-directed CAR T-cells developed to overcome that challenge have shown remarkable activity in antigen loss variants of leukemia and in patients with lymphoma who have progressed after CD19-targeting CAR T-cell therapy. However, the bispecific CAR T-cells targeting both CD19 and CD22 tested in the Phase I trial were not more effective than monospecific CAR T-cells and showed good potency on CD19 but not on CD22. It is thus important to design novel strategies to deliver bispecific CAR T-cells. This interview took place during the 36th Society for Immunotherapy of Cancer (SITC) Annual Meeting in Washington, D.C.
