The Acute Myeloid Leukemia Channel is supported with funding from BMS (Silver), and through an educational grant from Jazz Pharmaceuticals.
VJHemOnc is an independent medical education platform. Supporters, including channel supporters, have no influence over the production of content. The levels of sponsorship listed are reflective of the amount of funding given to support the channel.
ASH 2017 | Dual FLT3/SYK oral inhibitor for AML: TAK-659
SYK, which directly binds to and activates FLT3, has been implicated in the pathogenesis of B-cell malignancies, making it a promising therapeutic target. Speaking from the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition in Atlanta, GA, Dr Pratz discusses the study he presented (NCT02323113), which investigated mivavotinib (TAK-659), an oral dual SYK/FLT3 inhibitor, for relapsed or refractory acute myeloid leukemia (AML). Keith Pratz, MD, of Johns Hopkins University, Baltimore, MD, covers the promising suppression and clinical responses achieved so far, in FLT3-mutated and FLT3-unmutated patients.
