Paolo Milani, MD, PhD, Amyloidosis Research and Treatment Center, Pavia, Italy, comments on the impact of clonal features on the diagnosis, overall survival (OS), and hematologic event-free survival (EFS) of patients with non-cardiac AL amyloidosis, and highlights the importance of using this information to guide treatment decisions. This interview took place at the 2022 International Symposium on Amyloidosis (ISA) held in Heidelberg, Germany.