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General Updates | The potential use of nitrous oxide for pain management in sickle cell disease
In this video, Thiago Trovati Maciel, PhD, Research Director, Institut Imagine, Paris, France, discusses the potential use of nitrous oxide as an alternative to morphine for pain management in patients with sickle cell disease (SCD). Dr Maciel highlights that nitrous oxide is not associated with the addiction risk and side effects of morphine, which is widely used for managing SCD-associated pain. This interview took place virtually.
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Transcript
So today, the main complication of sickle cell disease is the pain. So patients that have severe pain, they are admitted to the hospital for this complication, and when they arrive in the hospital, usually they receive morphine. So we all know all the problems that we have with morphine and the addiction that some patients can develop with the morphine and also the side effects of this drug...
So today, the main complication of sickle cell disease is the pain. So patients that have severe pain, they are admitted to the hospital for this complication, and when they arrive in the hospital, usually they receive morphine. So we all know all the problems that we have with morphine and the addiction that some patients can develop with the morphine and also the side effects of this drug. So today we need some alternatives for the morphine and one of these alternatives is the nitrous oxide that can be applied to these patients. It can be used as a gas, inhalant gas, with new studies showing that we can also have oral administration of nitrous oxide to the patients. And what is interesting is that the side effects that we see with morphine, we don’t see with the nitrous oxide. So there is no addiction with this drug. So it’s a much more safe way to manage pain in the patients. And I think that with more clinical and preclinical research, in a few years, we can also provide to the patients other options to manage the pain instead of morphine.
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