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EMN 2021 | Impact of MYD88 and CXCR4 status on Waldenström’s macroglobulinemia

Steven Treon, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, gives an overview of his talk at EMN 2021 on the interconnection between genotype and phenotype in Waldenström’s macroglobulinemia. MYD88 mutations occur in about 90-97% of patients with Waldenström’s macroglobulinemia and CXCR4 mutations occur in 30-40% of patients. Dr Treon shares an overview of how mutational status can impact disease presentation, diagnostics and prognostics, as well as how it can be used as a predictor for response to BTK inhibitors. This interview took place during the 2021 European Myeloma Network (EMN) congress.


Steven Treon, MD, PhD, has received research support from Abbvie/Pharmacyclics, Beigene, BMS and Eli Lilly; and has received consultancy fees from Janssen, Abbvie/Pharmacyclics, Beigene, BMS and X4.

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