Hector Huerga Encabo, PhD, The Francis Crick Institute, London, UK, discusses a study investigating the impact of TET2 mutations on hematopoietic stem cell (HSC) resilience to immune-related stress. When TET2 mutant HSCs expand through clonal hematopoiesis (CH), neutrophil development and function are affected. Neutrophils harboring TET2 mutations produce exacerbated levels of inflammatory cytokines and exhibit a specific phenotype, with reduced phagocytic activity and aberrant neutrophil extracellular trap (NET) production. These NETs are smaller and more compact, restricting their degradation. Dr Encabo suggests that this lack of clearance of NETs from circulation may be associated with a higher risk of developing pathologies related to CH, such as leukemia and cardiovascular and pulmonary inflammatory diseases. This interview took place at the 64th Annual Scientific Meeting of the British Society for Haematology (BSH) Congress in Liverpool, UK.
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