The Acute Myeloid Leukemia Channel on VJHemOnc is an independent medical education platform, supported with funding from BMS (Silver), and through an educational grant from Jazz Pharmaceuticals. Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
SOHO 2018 | FLT3 inhibitors for treating AML
Currently, out of all FLT3 inhibitors, only midostaurin is FDA-approved for use in patients with acute myeloid lymphoma (AML). From the Society of Hematologic Oncology (SOHO) Annual Meeting, held in Houston, TX, Amir Fathi, MD, MPH, of Dana-Farber Cancer Institute, Boston, MA, emphasises that although midostaurin is a good FLT3 inhibitor, it lacks in selectivity and potency. In the RATIFY clinical trial (NCT00651261), however, Dr Fathi reports that midostaurin can enhance survival in AML patients when combined with 7+3 chemotherapy. Other FLT3 inhibitors such as crenolanib, gilteritinib, and quizartinib are not yet FDA- approved, but are undergoing testing in an advanced clinical phase study. Dr Fathi maintains that these drugs may join the future armamentarium of approved drugs that could be available for use in patients with FLT3 mutations.
