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EBMT 2024 | HHV-6 reactivation after haploidentical transplantation with PTCy & ATG: incidence and risk factors

Human herpesvirus type 6 (HHV-6) reactivation commonly occurs following transplantation and is associated with an increased likelihood of acute graft-versus-host-disease (GvHD) and delayed platelet engraftment. Rémy Duléry, MD, PhD, Saint-Antoine Hospital, Paris, France, discusses the findings of a study that aimed to assess whether treatment with post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) following haploidentical hematopoietic stem cell transplantation (SCT) increased the incidence of HHV-6 reactivation. The strongest predictive factor for HHV-6 reactivation in these patients was a low lymphocyte count at day +30. This interview took place at the 50th Annual Meeting of the EBMT in Glasgow, Scotland.

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