Jorge Castillo, MD, Dana-Farber Cancer Institute, Boston, MA, discusses current approaches for managing Waldenström’s macroglobulinemia (WM), highlighting uncertainties in treatment after frontline chemoimmunotherapy or BTK inhibitors. Dr Castillo mentions many drugs showing efficacy in the relapsed setting, including venetoclax, pirtobrutinib, and loncastuximab tesirine. He also mentions newer therapies, such as BTK degraders. This interview took place at the Twelfth Annual Meeting of the Society of Hematologic Oncology (SOHO 2024) congress in Houston, TX.
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