iwCLL 2023 | The use of surrogate endpoints in CLL clinical trials

Florian Simon, MD, University Hospital Cologne, Cologne, Germany, summarizes his talk on ‘endpoint surrogacy in chronic lymphocytic leukemia (CLL)’ presented at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2023 meeting, held in Boston, MA. Although overall survival (OS) is considered the most clinically relevant endpoint in clinical trials, surrogate endpoints such as progression-free survival (PFS) and measurable residual disease (MRD) could be useful tools to expedite trial readout. The analysis of twelve trials from the German CLL Study Group found a strong correlation between these surrogate endpoints and OS, which held true for both targeted therapies and chemoimmunotherapy (CIT). This interview took place at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2023 meeting, held in Boston, MA.

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