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EHA 2025 | The impact of microbiota disruption on outcomes in patients with secondary AML
Livio Pagano, MD, Catholic University of Sacred Heart, Rome, Italy, shares insights into how microbiota disruption can affect outcomes in secondary acute myeloid leukemia (AML). Prof. Pagano highlights that conventional chemotherapy can cause damage to the gastrointestinal tract and disrupt the microbiota, leading to infections that could increase the mortality rate among these patients. This interview took place at the 30th Congress of the European Hematology Association (EHA) in Milan, Italy.
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Transcript
Microbiota represent a very important point in the health of the patients with AML. And usually the conventional chemotherapy that we use for treating this kind of patients can cause damage to the gastrointestinal tract epithelium and, above all, to the microbiota. So, with a dysbiosis of this kind of agent, the consequence is a higher incidence of gastroenteric infection, neutropenic enterocolitis, that could be really dramatic in these patients and can cause an increase in the mortality rate for infection...
Microbiota represent a very important point in the health of the patients with AML. And usually the conventional chemotherapy that we use for treating this kind of patients can cause damage to the gastrointestinal tract epithelium and, above all, to the microbiota. So, with a dysbiosis of this kind of agent, the consequence is a higher incidence of gastroenteric infection, neutropenic enterocolitis, that could be really dramatic in these patients and can cause an increase in the mortality rate for infection.
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