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ASH 2025 | Real-world ibrutinib plus venetoclax in frontline CLL/SLL: REALITY-WW and REALITY-2 outcomes

Paolo Ghia, MD, Vita-Salute San Raffaele University, Milan, Italy, discusses early real-world outcomes with fixed-duration ibrutinib plus venetoclax in previously untreated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) from the REALITY worldwide (WW) and REALITY-2 cohort studies. He highlights high early response rates and a safety profile consistent with clinical trials, including in older patients. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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