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ICML 2023 | Molecular characterization of classical Hodgkin lymphoma
Lisa Roth, MD, Weill Cornell Medicine, New York, NY, explains the challenges in molecular characterization of classical Hodgkin lymphoma (cHL), which arise due to the rarity of malignant Reed-Sternberg cells. Dr Roth shares the key findings from recent whole exome and genome sequencing of Reed-Sternberg cells from cHL biopsies, including significant differences in mutational burden and mutational signatures across age groups. Younger patients showed a higher overall mutational burden and an accelerated rate of mutagenesis. The study also identified new driver alterations and explored the sequence of molecular events leading to the transformation of B cells into Reed-Sternberg cells. This interview took place at the 17th International Conference on Malignant Lymphoma (ICML), held in Lugano, Switzerland.
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