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ASH 2025 | Real-world effectiveness of Pola-R-CHP versus R-CHOP in older patients with DLBCL in the US

Matthew Matasar, MD, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, discusses the real-world effectiveness of polatuzumab vedotin (Pola) plus rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) compared to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in older patients with diffuse large B-cell lymphoma (DLBCL) in the United States. Dr Matasar highlights that the benefits of the Pola-R-CHP regimen, established in the POLARIX clinical trial (NCT03274492), appear to translate to the real-world setting. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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