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ASH 2025 | Patient-informed CRISPR screening reveals gene targets to improve CAR T-cell efficacy

Joseph Melenhorst, PhD, Cleveland Clinic, Cleveland, OH, describes a CRISPR-based strategy to identify genes that enhance CAR T-cell proliferation and antitumor activity. The work has yielded promising targets now advancing toward preclinical development. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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