Lakshmi Nayak, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the current standard of care (SoC) in patients with primary central nervous system (CNS) lymphoma, which includes two phases, induction followed by consolidation. Induction chemotherapy often involves high-dose methotrexate-based regimens aiming to achieve complete response (CR). For consolidation, there are three main regimens: autologous stem cell transplantation (autoSCT) for young and fit patients, whole brain radiation, or chemotherapy. Dr Nayak hopes novel therapies being investigated in the relapsed/refractory (R/R) setting will be brought into frontline treatment to reduce recurrence. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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