Jorge Castillo, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the role of BTK inhibitors (BTKis) in the treatment of Waldenström’s macroglobulinemia (WM), highlighting the effectiveness of ibrutinib, acalabrutinib, and zanubrutinib. Dr Castillo emphasizes that dose reductions can be used as a strategy to optimize treatment with BTKis, especially in older patients and women. Genomic profiling, particularly for MYD88, CXCR4, and TP53 mutations, is becoming a key tool in treatment decisions. This interview took place at the Twelfth Annual Meeting of the Society of Hematologic Oncology (SOHO 2024) congress in Houston, TX.
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