The Non-Malignant Channel on VJHemOnc is an independent medical education platform, supported with funding from Agios (Gold). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
The Sickle Cell Disease Channel on VJHemOnc is an independent medical education platform, supported with funding from Agios (Gold). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
ASCAT 2024 | The potential of mitapivat and other pyruvate kinase activators in SCD
Enrico Novelli, MD, MS, University of Pittsburgh, Pittsburgh, PA, discusses the development of mitapivat, a drug approved for pyruvate kinase deficiency, which shows promise for treating sickle cell disease (SCD). Although not yet approved for SCD, Dr Novelli highlights that both first- and second-generation pyruvate kinase activators have demonstrated an encouraging ability to increase hemoglobin and reduce hemolysis and will hopefully also lead to improvements in vaso-occlusive episodes and disease-related complications. This interview took place at the 19th Annual Scientific Conference of the Academy for Sickle Cell and Thalassaemia (ASCAT 2024) in London, UK.
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Disclosures
Advisor/consultant for Novo Nordisk, Chiesi Pharmaceuticals and Shield Therapeutics.
