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ASH 2025 | Does current bulk NGS monitoring fail to detect emerging subclones driving relapse in AML?
Koichi Takahashi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, briefly comments on the effectiveness of bulk next-generation sequencing (NGS) for detecting and monitoring emerging subclones driving relapse in acute myeloid leukemia (AML). He suggests that, while single-cell analysis can provide more granular information on clonal relationships and dynamics, bulk sequencing remains a valuable tool, and its sensitivity is improving. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.
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Transcript
I don’t think the current bulk sequencing fails to detect these emerging subclones. Actually, bulk sequencing does a good job. And now that a lot of institutions or labs are performing these bulk sequencing with error-corrected methods, I think the sensitivity of detecting these emerging subclones is really improving. So it’s not like that bulk sequencing fails to detect these emerging subclones...
I don’t think the current bulk sequencing fails to detect these emerging subclones. Actually, bulk sequencing does a good job. And now that a lot of institutions or labs are performing these bulk sequencing with error-corrected methods, I think the sensitivity of detecting these emerging subclones is really improving. So it’s not like that bulk sequencing fails to detect these emerging subclones. Yes, if we do single-cell analysis, we can, in addition, not only detect the emerging clones, but in the context of other clones, so clonal relationship, clonal dynamics, we can see that a little bit more granular. However, I think the current bulk sequencing technology still is able to do a good job and it’s also doing a better job these days of detecting these emerging clones.
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