The Chronic Lymphocytic Leukemia Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), AbbVie (Platinum), BeOne Medicines (Silver) and Lilly (Silver). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
The Lymphoma Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), BMS (Gold), Johnson & Johnson (Gold), Takeda (Silver) and Galapagos (Bronze). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
ASH 2023 | The safety & efficacy of copanlisib + nivolumab in patients with RT and tNHL: a chemo-free approach
Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, discusses the Phase I trial (NCT03884998) investigating the maximum tolerated dose (MTD) of copanlisib, a P13K inhibitor, combined with nivolumab, a PD-1 antagonist, to treat patients with Richter’s transformation (RT) or transformed non-Hodgkin lymphoma (tNHL). Prof. Danilov outlines the exploratory objectives of the trial, including determining preliminary efficacy, dose-limiting toxicities (DLT), and T-cell functionality. Although copanlisib has now been withdrawn from the market, this study highlights that a chemotherapy-free approach is feasible in this patient population. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: MEI, Lilly Oncology, Nurix, Abbvie, Beigene, Janssen, Astra Zeneca, Bristol Meyers Squibb, Genentech, GenMab, Merck
Research Funding: MEI, Lilly Oncology, Cyclacel, Bayer, Nurix, Abbvie, Beigene, Astra Zeneca, Bristol Meyers Squibb, GenMab
