ASH 2022 | Update on Phase I/II study of azacitidine, venetoclax and gilteritinib in patients with FLT3+ AML
Farhad Ravandi, MD, University of Texas MD Anderson Cancer Center, Houston, TX, outlines updated results from a Phase I/II study evaluating the triplet regimen of azacitidine, venetoclax and gilteritinib in elderly and unfit patients with newly diagnosed or relapsed/refractory (R/R) FLT3-mutated acute myeloid leukemia (AML). Overall, the novel combination was shown to be effective in the frontline setting for patients with FLT3-mutated AML, achieving high response rates (RR) that were durable. Dr Ravandi also anticipates that in the future, this novel regimen could be used for younger patients with FLT3-mutated AML to achieve remission before proceeding to allogeneic stem cell transplantation. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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Disclosures
Xencor: Research Funding; Prelude: Research Funding; Astex/Taiho: Membership on an entity’s Board of Directors or advisory committees, Research Funding; Abbvie: Consultancy, Honoraria, Research Funding; AstraZeneca: Consultancy; Amgen: Honoraria, Research Funding; Novartis: Consultancy; BMS/Celgene: Consultancy, Honoraria, Research Funding; Amgen: Honoraria, Research Funding; Syos: Consultancy, Honoraria, Research Funding; Astellas: Consultancy, Honoraria, Research Funding; Biomea Fusion, Inc.: Research Funding.
