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ASCO 2024 | Is there a benefit to rituximab maintenance after first-line bendamustine-rituximab for MCL?
Yucai Wang, MD, PhD, Mayo Clinic, Rochester, MN, discusses the benefit of rituximab maintenance after first-line bendamustine-rituximab in patients with mantle cell lymphoma (MCL). Previous data was varied, as the MAINTAIN trial (NCT00877214) showed no overall survival (OS) or progression-free survival (PFS) benefit with rituximab maintenance, but several small cohort retrospective studies had. Dr Wang presents the results from a large observational multi-center study in a cohort of patients who had not progressed three months after the end of bendamustine-rituximab therapy. At the five-year follow-up, rituximab maintenance was associated with improved OS and event-free survival (EFS), statistically significant in patients achieving a complete response (CR). This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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