Anand Patel, MD, University of Chicago Medical Center, Chicago, IL, discusses ongoing and upcoming trials for patients with myeloproliferative neoplasms (MPNs) in the accelerated or blast-phase (MPN-AP/BP). Recent studies have explored the use of hypomethylating agents (HMAs) in combination with ruxolitinib, as well as targeted approaches using JAK and IDH2 inhibition. Dr Patel highlights how the results of these trials are encouraging but emphasizes the importance of preclinical research identifying new potential treatment targets. This interview took place at the 1st Annual MPN Workshop of the Carolinas in Asheville, NC.
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