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ERIC 2020 | Understanding CLL pathogenesis by assessing clonotypes

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Andreas Agathangelidis

Andreas Agathangelidis, PhD, Center for Research and Technology Hellas, Thermi, Greece, discusses how clonotypes can be used to assess biological and clinical roles in chronic lymphocytic leukemia (CLL) and how they affect disease development. By scanning healthy, preleukemic individuals the deterioration of the immune system can be assessed. The immunoglobulin sequences present in CLL were found in very few of the healthy individuals scanned. They were only found in immature B-cells, suggesting that, in healthy individuals, the immune system excludes these sequences in mature B-cells that could threaten homeostasis. This interview took place during the European Research Initiative on CLL (ERIC) International Virtual Meeting 2020.

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