ICML 2023 | Predictors of long-term survival in patients with DLBCL/HGBCL following autoSCT

So for the patients receiving stem cell transplant in that arm of our analysis, we saw that those with a history of low grade or indolent lymphoma prior to developing diffuse large or high grade B cell lymphoma seem to have improved outcomes after stem cell transplantation, and that was significant. What was also significant, though, was that other high-risk factors that would predict for failure of second line chemo prior to stem cell transplant did not seem to reduce the survival outcomes or the progression-free survival of patients who receive stem cell. So, for instance, those who are primary refractory or relapsed within 12 months of diagnosis seem to have equivalent outcomes if they made it to stem cell transplant as compared to those with later relapses. Similarly, those that did not have a CR after salvage chemotherapy seem to have similar outcomes if they went on to stem cell transplant as compared to those who had a CR and other similar predictive factors for a lower likelihood of response to salvage chemo did not seem to predict for relapse after stem cell transplant for the patients who received it.