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ASH 2024 | Safety and efficacy of autoSCT in systemic sclerosis

Eleni Gavriilaki, MD, PhD, Aristotle University of Thessaloniki, Thessaloniki, Greece, comments on the long-term safety and efficacy of autologous stem cell transplantation (autoSCT) for patients with systemic sclerosis. Dr Gavriilaki emphasizes the encouraging results of her center’s experience with autoSCT in systemic sclerosis, including low treatment-related mortality and the ability of patients to discontinue immunosuppressive therapy. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.

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Transcript (AI-generated)

We are very happy to present our long-term data on autologous transplantation for patients with systemic sclerosis. Our centre has been innovative in this approach with autoimmune diseases in general. We are the first ones to start autologous transplant in multiple sclerosis and then after some years we moved to systemic sclerosis. This is an update of our data for quite a good number of patients for this rare indication...

We are very happy to present our long-term data on autologous transplantation for patients with systemic sclerosis. Our centre has been innovative in this approach with autoimmune diseases in general. We are the first ones to start autologous transplant in multiple sclerosis and then after some years we moved to systemic sclerosis. This is an update of our data for quite a good number of patients for this rare indication. We believe that autologous transplant may have significant benefits for these patient populations. Of course, our abstract highlights that we need to select patients based on strict criteria. And we also encourage other referral physicians to actively select their patients and refer to us as early as possible when they have an indication for transplant. In total, we have shown very good efficacy and also safety for these patients. Some of the patients were able to stop immunosuppressive therapy after transplant and we observed a very low treatment-related mortality in our patient population.

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Disclosures

AstraZeneca Pharmaceuticals: Honoraria; Omeros Pharmaceuticals: Honoraria; Sanofi Pharmaceuticals: Honoraria; Sobi Pharmaceuticals: Honoraria; Jazz Pharmaceuticals: Research Funding.