Maria Carolina Florian, PhD, of IDIBELL Bellvitge Biomedical Research Institute, Barcelona, Spain, discusses ageing in hematopoietic stem cells and their changing capacities to regenerate the hematopoetic system. Furthermore, Dr Florian outlines the role of epigenetics and the microenvironment on this change. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).