ASH 2023 | 131I-apamistamab-led induction/conditioning prior to alloSCT in R/R AML: insights from SIERRA
Mark Litzow, MD, Mayo Clinic, Rochester, MN, presents findings from the Phase III SIERRA trial (NCT02665065), evaluating targeted radiation with 131I-apamistamab prior to non-myeloablative allogeneic stem cell transplantation (alloSCT), versus conventional chemotherapy, in patients ≥55 years old with relapsed/refractory (R/R) acute myeloid leukemia (AML). High liver doses of this treatment regimen (≥22 Gy) yielded durable complete remission (CR) rates, establishing 131I-apamistamab followed by alloSCT as a new standard of care. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Amgen: Research Funding, Consultancy; Astellas: Research Funding; Novartis: Research Funding; Syndax: Research Funding; Jazz: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Actinium: Research Funding; Pluristem: Research Funding; Biosight: Consultancy, Other: Data Monitoring Board; Abbvie: Research Funding; Beigene: Consultancy.
