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ASH 2025 | Phase II results of rituximab and epcoritamab as 1L therapy for patients with high-tumor-burden FL

Reid Merryman, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the results of a Phase II study (NCT05783609) evaluating rituximab pretreatment followed by epcoritamab in newly diagnosed, high-tumor-burden follicular lymphoma (FL). The time-limited regimen demonstrated promising results, with high response rates and a tolerable safety profile, supporting a potential chemotherapy-free first-line (1L) approach for selected patients. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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