Catherine C. Coombs, MD, The University of North Carolina Cancer Center, Chapel Hill, NC, discusses the pharmacokinetics of the highly-selective non-covalent Bruton’s tyrosine kinase inhibitor (BTKi), pirtobrutinib, and explains how the mechanism of action of this next-generation BTKi can offer superior outcomes and quality of life. Pirtobrutinib has a 300-fold greater selectivity for BTK compared to other kinases on the kinome selectivity map, indicating fewer off-target effects and thus having a more favorable safety profile. This interview took place during the ninth annual meeting of the Society of Hematologic Oncology (SOHO 2021) congress.