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ASH 2022 | MRD-guided therapy in patients with intermediate-risk AML compared to unguided cohort using PSM

Jesse Tettero, MD, PhD, Amsterdam UMC, Amsterdam, The Netherlands, shares the findings of a study investigating measurable residual disease (MRD)-guided therapy in patients with intermediate-risk acute myeloid leukemia (AML) compared to unguided cohort using propensity score matching (PSM). In the HOVON-SAKK-132 trial (EUDRACT2013-002843-26), MRD-negative patients received autologous stem cell transplantation, whereas MRD-positive patients received allogeneic stem cell transplantation. Whilst there was no significant difference in relapse-free survival between these two groups, results from the propensity score matching (PSM) analysis showed that patients who are MRD-negative can undergo reduced-intensity conditioning autologous transplantation without an impact on survival outcomes. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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