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EHA 2023 | Causes & management of ibrutinib discontinuation in CLL

Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, comments on the causes for ibrutinib discontinuation in chronic lymphocytic leukemia (CLL), explaining how to manage this situation. Dr Scarfò explains that patients may discontinue this agent due to either intolerance or progression. While patients who progress on ibrutinib may be treated with venetoclax, patients who are intolerant to ibrutinib might either be followed up or treated with another covalent BTK inhibitor depending on their disease status. This interview took place at the 28th Congress of the European Hematology Association (EHA) 2023 in Frankfurt, Germany.

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Advisory board: AbbVie, AstraZeneca, BeiGene, Janssen, Lilly Speaker bureau: Octapharma