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EHA 2024 | Menin inhibitors in AML: mechanism of action, the current key data, and predicting efficacy
Menin inhibitors are a hot topic in the field of acute myeloid leukemia (AML), with the potential to provide a novel treatment option for patients with this malignancy. Harry Erba, MD, PhD, Duke University, Durham, NC, briefly outlines the mechanism of action of menin inhibitors before discussing some of the current data on menin inhibition in AML. Dr Erba provides insight into a study investigating DSP-5336 (NCT04988555), as well as mentioning the BEAT AML trial (NCT03013998), which combines revumenib with azacitidine and venetoclax in newly diagnosed older patients. There is also growing interest in identifying an expression signature that may predict the efficacy of menin inhibitors. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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Disclosures
Research Funding: Forma, Novartis, Amgen, Macrogenics, Servier, Kura Oncology, ALX Oncology, Gilead, Jazz Pharma, Forty-Seven, Ascentage, Immunogen, Glycomimetics, Celgene, Agios, Daiichi Sankyo Inc., AbbVie, PTE, Sumitomo; Consultancy: Novartis, Macrogenics, Syros, Servier, Kura Oncology, Trillium, Takeda, Pfizer, Incyte, Immunogen, Glycomimetics, Genentech, BMS, Celgene, Astellas, Agios, Daiichi Sankyo Inc., AbbVie; Honoraria: Novartis, Servier, Jazz Pharma, Sunesis Pharmaceuticals, Incyte, Glycomimetics, BMS, Celgene, Agios, AbbVie; Membership on an entity’s Board of Directors or advisory committees: Glycomimetics, AbbVie; Other: BMS (Chair, Myeloid Neoplasms Repository Study), Celgene (Chair, Myeloid Neoplasms Repository Study); Speakers Bureau: AbbVie.
