Timothy Hughes, MD, of the Royal Adelaide Hospital, Adelaide, Australia, gives us an overview of the follow-up study of ENESTcmr. The ENESTop trial (NCT01698905) was designed to address whether deep molecular response in chronic myeloid leukemia (CML) could be translated into treatment-free remission (TFR). Over 50% of patients who started on imatinib and had switched to nilotinib remained in TFR. This suggests that switching a patient onto a diffeent tyrosine kinase inhibitor, in order to achieve a deaper response, will eventually translate into acheiving higher rates of TFR. This video was recorded at the 23rd congress of European Hematology Association (EHA) 2018, held in Stockholm, Sweden.