Alexandros Spyridonidis, MD, University of Patras, Patras, Greece, discusses the feasibility of lowering the total body irradiation (TBI) dose from the standard 12 Gy as conditioning for allogeneic hematopoietic stem cell transplantation (alloHSCT) in young adult patients with acute lymphoblastic leukemia (ALL). In a recent study comparing patients receiving fludarabine and either 12 Gy or 8 Gy of radiation, patients receiving the latter dose had superior overall survival (OS) and graft-versus-host disease (GvHD) survival rates as well as lower incidences of mortality. This interview took place at the 7th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) in Berlin, Germany.
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